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Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospectivecohort study

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

《医学前沿（英文）》 2020年 第14卷 第6期   页码 802-810 doi: 10.1007/s11684-019-0723-7

摘要： The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown. This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai, China. Oral glucose tolerance test was conducted during baseline and follow-up visits. Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk. A total of 613 (10.3%) incident diabetes cases were identified during the follow-up visit after 4.5 years. Fasting plasma glucose, postload glucose, and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid (all s<0.05). The incidence rate of diabetes increased across the quartiles of serum uric acid (7.43%, 8.77%, 11.47%, and 13.43%). Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid (odds ratio (95% confidence interval) = 1.36 (1.06−1.73)). Stratified analysis indicated that the association was only observed in women. Accordingly, serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women.

关键词： incident diabetes     prospective study     uric acid    

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dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospectivecohort study

《医学前沿（英文）》 2022年 第16卷 第5期   页码 714-722 doi: 10.1007/s11684-021-0888-8

摘要： A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposed. We aim to examine the associations of MAFLD, particularly its discordance from non-alcoholic fatty liver disease (NAFLD), with the progression of elevated brachial-ankle pulse wave velocity (baPWV) and albuminuria in a community-based study sample in Shanghai, China. After 4.3 years of follow-up, 778 participants developed elevated baPWV and 499 developed albuminuria. In comparison with the non-MAFLD group, the multivariable adjusted odds ratio (OR) of MAFLD group for new-onset elevated baPWV was 1.25 (95% confidence interval (CI) 1.01–1.55) and 1.35 (95% CI 1.07–1.70) for albuminuria. Participants without NAFLD but diagnosed according to MAFLD definition were associated with higher risk of incident albuminuria (OR 1.77; 95% CI 1.07–2.94). Patients with MAFLD with high value of hepamet fibrosis score or poor-controlled diabetes had higher risk of elevated baPWV or albuminuria. In conclusion, MAFLD was associated with new-onset elevated baPWV and albuminuria independently of body mass index, waist circumference, and hip circumference. Individuals without NAFLD but diagnosed as MAFLD had high risk of albuminuria, supporting that MAFLD criteria would be practical for the evaluation of long-term risk of subclinical atherosclerosis among fatty liver patients.

关键词： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score     brachial-ankle pulse wave velocity     albuminuria    

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Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospectivecohort study

《医学前沿（英文）》   页码 867-877 doi: 10.1007/s11684-023-0995-9

摘要： Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of inactivated vaccines is not well characterized in people with comorbidities, who are at high risk of severe infection. We compared the risk of SARS-CoV-2 infection after complete vaccination with Sinopharm/BBIBP in people with comorbidities (e.g., autoimmune diseases, cardiovascular disease, chronic lung disease, and diabetes) with healthy individuals using a Cox-proportional hazard model. In July–September 2021, a total of 10 548 people (comorbidities, 2143; healthy, 8405) receiving the complete primary series of vaccination with Sinopharm/BBIBP in Bangkok, Thailand were prospectively followed for SARS-CoV-2 infection through text messaging and telephone interviewing for 6 months. A total of 295 infections from 284 participants were found. HRs (95% CI) of individuals with any comorbidities did not increase (unadjusted, 1.02 (0.77–1.36), P = 0.89; adjusted, 1.04 (0.78–1.38), P = 0.81). HRs significantly increased in the subgroup of autoimmune diseases (unadjusted, 2.64 (1.09–6.38), P = 0.032; adjusted, 4.45 (1.83–10.83), P = 0.001) but not in cardiovascular disease, chronic lung disease, or diabetes. The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with any comorbidities vs. healthy individuals. However, the protection appeared lower in the subgroup of autoimmune diseases, which may reflect suboptimal immune responses among these people.

关键词： COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

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for allogeneic peripheral stem cell transplantation for adult patients with lymphoid malignancies: a prospectivesingle-arm phase II study

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

《医学前沿（英文）》 2021年 第15卷 第1期   页码 108-115 doi: 10.1007/s11684-019-0730-8

摘要： Post-transplantation cyclophosphamide (PT-Cy) alone or in combination with other immunosuppressive drugs has emerged as a promising strategy in the setting of allogeneic hematopoietic stem cell transplantation. Improved survival rate was reported in lymphoid malignancies following PT-Cy strategy compared with myeloid disease in non-myeloablative bone marrow transplant setting. Thus, we aimed to evaluate the safety and efficacy of PT-Cy combined with cyclosporine as graft-versus-host disease (GVHD) prophylaxis after myeloablative conditioning and T cell-replete peripheral stem cell transplantation in lymphoid malignancies. This single-arm phase II clinical trial (NCT01435447) involving 31 adult patients was conducted from January 2013 to June 2018. The donor-type neutrophil engraftment rate was 100%, and the overall incidence of grade II to IV and grade III to IV acute GVHD was 39% and 24%, respectively. The cumulative incidence rates of chronic GVHD (35%), including moderate to severe forms (10%), were reduced compared with those of the historical group ( =0.03 and =0.04, respectively). With a median follow-up of 18 months, the estimated 2-year overall and event-free survival was 64.8% (95% confidence interval: 47.8%–86.7%) and 58.4% (95% CI: 41.9%–81.7%), respectively. The 2-year cumulative incidence rate of relapse was 19.5% (95% CI: 9.0%–35.8%), whereas the non-relapse mortality rate was 21.8% (95% CI: 11.3%–38.1%). These results demonstrated the feasibility of PT-Cy as GVHD prophylaxis in this clinical setting. This strategy could significantly reduce the incidence of chronic GVHD and its moderate to severe forms but not of acute GVHD and results in similar survival outcomes compared with the historical group. A prospective study with additional patients is warranted to confirm the role of PT-Cy in lymphoid malignancy.

关键词： post-transplantation cyclophosphamide     allogeneic hematopoietic stem cell transplantation     lymphoid malignancies    

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aspiration to key hole craniotomy in the surgical treatment of spontaneous putaminal hemorrhage: a prospectiverandomized study

ZHAO Jizong, WANG Dejiang, WANG Shuo, YUAN Ge, KANG Shuai, JI Nan, ZHAO Yuanli, YE Xun, ZHOU Liangfu, ZHOU Dingbiao, WANG Renzhi, WANG Mei

《医学前沿（英文）》 2007年 第1卷 第2期   页码 142-146 doi: 10.1007/s11684-007-0027-1

摘要： This study was designed to compare the approaches and efficacies of two different ways of neurosurgical management for spontaneous putaminal hemorrhage (SPH): computed tomographic-guided aspiration (CTGA) and the key-hole approach (KHA). The indications of the two approaches are also explored. From September 2001 to 2003, a total of 1077 cases of SPH distributed in 135 hospitals all over the mainland of China were included for analysis. All cases had three-month follow-up data. The study was designed in a single-blinded manner to compare the efficacies of the different approaches. There were 563 cases in the CTGA group, 165 in the KHA group, and 217 cases in the conventional open craniotomy (COC) group. In the CTGA and KHA groups, the mortalities at one month after operation (M1m) were 17.9% and 18.3%, respectively, while the mortalities at three months after operation (M3m) were 19.4% and 19.4%, respectively (>0.05). The postoperative complications due to CTGA (23.7%) were not significantly different from those due to KHA (25.7%) ( = 0.420). The M3m of patients with Glasgow coma scale (GCS) "d8 was 3.45 and 4.0 times as much as those with GCS>8, respectively. The M3m of patients with complications was 3.92 times as much as those without complications. The M3m of patients with hemorrhage volume "e70 mL was 2.67 times as much as those <70 mL. The CTGA is not better than KHA in the treatment of SPH in terms of a more favorable outcome or less mor tality and morbidity, but CTGA could be the first choice for those with bleeding volumes "d50mL, while KHA is the first choice for those with bleeding volumes >50 mL.

关键词： tomographic-guided aspiration     single-blinded manner     favorable outcome     operation     Glasgow    

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during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma: a prospectivecohort study

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

《医学前沿（英文）》 2021年 第15卷 第1期   页码 101-107 doi: 10.1007/s11684-020-0752-2

摘要： Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels. We tested therefore the protective effect of suppressing TSH with L-thyroxine during RT for medulloblastoma/PNET and Hodgkin lymphoma (HL) in a prospective cohort study. From 1998 to 2001, a total of 37 euthyroid children with medulloblastoma/PNET plus 14 with HL, scheduled for craniospinal irradiation and mediastinum/neck radiotherapy, respectively, underwent thyroid ultrasound and free triiodothyronine (FT3), free thyroxine (FT4), and TSH evaluation at the beginning and end of craniospinal iiradiation. From 14 days before and up to the end of radiotherapy, patients were administered L-thyroxine checking every 3 days TSH to ensure a value<0.3 μIU/mL. During follow-up, blood tests and ultrasound were repeated; primary hypothyroidism was considered an increased TSH level greater than normal range. Twenty-two/37 patients with medulloblastoma/PNET and all the 14 patients with HL were alive after a median 231 months from radiotherapy with 7/22 and 8/14 having correctly reached TSH levels ˂ 0.3 μIU/mL and well matched for other variables. Twenty years on, hypothyroidism-free survival rates differed significantly, being 60%±15% and 15.6%±8.2% in TSH-suppressed vs. not-TSH suppressed patients, respectively ( =0.001). These findings suggest that hypothyroidism could be durably prevented in two populations at risk of late RT sequelae, but it should be confirmed in a larger cohort.

关键词： iatrogenic primary hypothyroidism     late effects of radiotherapy     long-term follow-up     medulloblastoma     Hodgkin lymphoma    

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Prospective research on the efficacy and safety of oxcarbazepine as monotherapy and add-on therapy for

Huicong KANG, Xiaoyan LIU, Hu QI, Feng XU, Xiang LI, Yuan WANG, Zhiguang LIU, Suiqiang ZHU

《医学前沿（英文）》 2009年 第3卷 第2期   页码 181-186 doi: 10.1007/s11684-009-0025-6

摘要： The purpose of our research was to evaluate the efficacy, tolerance, and safety of oxcarbazepine (OXC) as monotherapy and add-on therapy for partial epilepsy. We carried out a prospective clinical follow-up trial at the Epilepsy Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Sixty-seven patients with partial epilepsy received OXC therapy. The patients were randomly divided into a monotherapy group and an add-on therapy group. We observed the efficacy and safety in the first three months and the following three months respectively, and compared them with each other. There was a significant difference in the decrease of seizure frequency between the two groups ( = 0.002). There was a significant difference in the percentage of seizure-free between the monotherapy and the add-on therapy groups in the first three months ( = 0.02), and there were also statistical differences in the 50% response rate ( = 0.017) and the percentage of seizure-free in the following three months ( = 0.019). No difference was found in the 50% response rate, the 75% response rate, and the percentage of seizure-free between the first three months and the following three months in the whole group and the two subgroups ( > 0.05). The incidence rate of side effects due to the therapy was 19.40% (13 of 67). The side effects were mainly found in the first three months. It is concluded that OXC is the first-line anti-epileptic drug (AED) for partial seizures, and could be used as the monotherapy and add-on therapy for newly diagnosed patients and patients that failed to tolerate or benefit from other AEDs.

关键词： oxcarbazepine     partial epilepsy    

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厦金大桥地区地震危险性远景探讨

彭阜南,叶银灿,潘国富,刘杜娟

《中国工程科学》 2005年 第7卷 第5期   页码 16-23

摘要：

厦门—金门及其邻近地区的现代地震特征虽已有讨论，但是自1999年9月21日台湾西部集集发生大地震（M=7.3）之后，促使人们考虑厦金地区在未来大桥工程修成之后的长期运转过程中，是否有更大地震发生而受到波及？这就需要从厦金地区周边更大的区域来进行分析。文章试图从台湾海峡地震内部成因、大陆福建沿岸的地震和台湾造山带内经常发生的较大地震可能对本区造成的危害进行探讨。

关键词： 厦金大桥     台湾海峡     地震危险性    

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Scale study of sites and pavilions for World Expo 2010

ZHOU Zhuoyan, CHEN Yi

《结构与土木工程前沿（英文）》 2008年 第2卷 第1期   页码 102-106 doi: 10.1007/s11709-008-0012-z

摘要： The scale of sites and pavilions for World Expo 2010 (Shanghai World Expo) mainly refers to the study of their size including the area and number of exhibition hall needed in each pavilion and site with appropriate waiting area. All the design data of scale studied should reasonably meet the requirements during World Expo 2010 to accommodate large number of people for visiting and waiting to the full.

关键词： pavilion     study     number     appropriate     design    

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Practicality study on air-powered vehicle

LIU Lin, YU Xiaoli

《能源前沿（英文）》 2008年 第2卷 第1期   页码 14-19 doi: 10.1007/s11708-008-0004-7

摘要： To investigate the feasibility and outlook of air-powered vehicles including compressed air-powered vehicle and liquid nitrogen-powered vehicle, thermodynamic analysis and experiment data were used to analyze the energy density, performance, safety, running efficiency, fuel circulation economy and consumer acceptance, etc. The results show that compressed air and liquid nitrogen have similar energy density as Ni-H battery; the characteristics of an air-powered engine is suitable for driving a vehicle; the circulation efficiency of liquid nitrogen is 3.6%–14% and that of compressed air is 25%–32.3% in practice, and existing technology can assure its safety. It is concluded that though the performance of an air-powered engine is inferior to that of the traditional inert combustion engine, an air-powered vehicle is fit for future green cars to realize the sustainable development of society and environment.
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Experimental study on shear behavior of prestressed reactive powder concrete I-girders

Hui ZHENG, Zhi FANG, Bin CHEN

《结构与土木工程前沿（英文）》 2019年 第13卷 第3期   页码 618-627 doi: 10.1007/s11709-018-0500-8

摘要： As a new generation of concrete, RPC(Reactive Powder Concrete) has attracted great research attention for its ultra-high strength and high durability. In the present paper, experimental results from tests on eight prestressed RPC I-section girders failing in shear are reported herein. The beams with RPC of 120 MPa in compression were designed to assess the ability to carry shear stress in thin webbed prestressed beams with stirrups. The test variables were the level of prestressing, shear span-depth ratio ( / ) and stirrup ratio. Shear deformation, shear capacity and crack pattern were experimentally investigated in detail. With regard to the shear resistance of the test beams, the predictions from three standards (AFGC, JSCE and SIA) on the design of UHPC structures were compared with the experimental result suggesting that the experimental strength is almost always higher than predicted. RPC, as a new concrete, was different from normal concrete and fiber reinforced concrete. Further study should be needed to develop an analytical method and computation model for shear strength of RPC beams.

关键词： prestressed concrete     RPC(Reactive Powder Concrete)     concrete beams     shear strength     experimental study    

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A feasibility study of the measuring accuracy and capability of wireless sensor networks in tunnel monitoring

Xiaojun LI, Zhong JI, Hehua ZHU, Chen GU

《结构与土木工程前沿（英文）》 2012年 第6卷 第2期   页码 111-120 doi: 10.1007/s11709-012-0150-1

摘要： Fire disasters and the deterioration of tunnel structures are major concerns for tunnel operation and maintenance. Traditional wired monitoring systems have many drawbacks in terms of installation time, overall cost, and flexibility in tunnel environments. In recent years, there has been growing interest in the use of wireless sensor networks (WSNs) for the monitoring of various structural monitoring applications. This paper evaluated the feasibility of applying a WSN in the monitoring of tunnels. The monitoring requirements of tunnels under explosion and combustion fire scenarios are analyzed using numerical simulation, and the maximum possible distance for temperature sensors is derived. The displacement monitoring of tunnels using an inclinometer is investigated. It is recommended that the inclinometer should be installed in the 1/4 span of the tunnel structure. The maximum wireless transmission distances in both outdoor and tunnel environments were examined. The influences of surface materials and sensor node locations on the data transmission distance in tunnel environments were also investigated. The experimental results show that the data loss in tunnel environments is approximately three times that in outdoor environments. Surface material has a considerable influence on the transmission distance of radio signals. The distance is 25 ? 28 m for a raw concrete surface, 20 m for a brick surface, and 36 m for a terrazzo surface. The transmission distances along the middle of quarter points are approximately 0.9 ( is the transmission distance in the center of the tunnel), and the relative error is less than±3%. The transmission distances at different locations along the bottom exhibit significant differences, decreasing from the middle to the corner point, with distances of approximately 0.8 at the quarter points and minimum distances of approximately 0.55 at the corner points.

关键词： wireless sensor network (WSN)     tunnel     monitoring     feasibility study    

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Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 517-521 doi: 10.1007/s11684-016-0480-9

摘要：

This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.

关键词： antimicrobial susceptibility/resistance     Propionibacterium acnes     topical antibiotics     in vitro study    

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Genetic study and molecular breeding for high phosphorus use efficiency in maize

null

《农业科学与工程前沿（英文）》 2019年 第6卷 第4期   页码 366-379 doi: 10.15302/J-FASE-2019278

摘要：

Phosphorus is the second most important macronutrient after nitrogen and it has many vital functions in the life of plants. Most soils have a low available P content, which has become a key limiting factor for increasing crop production. Also, low P use efficiency (PUE) of crops in conjunction with excessive application of P fertilizers has resulted in serious environmental problems. Thus, dissecting the genetic architecture of crop PUE, mining related quantitative trait loci (QTL) and using molecular breeding methods to improve high PUE germplasm are of great significance and serve as an efficient approach for the development of sustainable agriculture. In this review, molecular and phenotypic characteristics of maize inbred lines with high PUE, related QTL and genes as well as low-P responses are summarized. Based on this, a breeding strategy applying genomic selection as the core, and integrating the existing genetic information and molecular breeding techniques is proposed for breeding high PUE maize inbred lines and hybrids.

关键词： maize     phosphorus use efficiency     quantitative trait loci     genetic study     molecular breeding     genomic selection    

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Parametric study on seismic performance of self-centering reinforced concrete column with bottom-placed

《结构与土木工程前沿（英文）》   页码 1145-1162 doi: 10.1007/s11709-023-0945-2

摘要： To realize seismic-resilient reinforced concrete (RC) moment-resisting frame structures, a novel self-centering RC column with a rubber layer placed at the bottom (SRRC column) is proposed herein. For the column, the longitudinal reinforcement dissipates seismic energy, the rubber layer allows the rocking of the column, and the unbonded prestressed tendon enables self-centering capacity. A refined finite element model of the SRRC column is developed, the effectiveness of which is validated based on experimental results. Results show that the SRRC column exhibits stable energy dissipation capacity and no strength degradation; additionally, it can significantly reduce permanent residual deformation and mitigate damage to concrete. Extensive parametric studies pertaining to SRRC columns have been conducted to investigate the critical factors affecting their seismic performance.

关键词： seismic resilience     self-centering     rubber layer     flag-shaped hysteresis loop     parametric study    

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标题 作者 时间 类型 操作

Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospectivecohort study

Di Cheng, Chunyan Hu, Rui Du, Hongyan Qi, Lin Lin, Xueyan Wu, Lina Ma, Kui Peng, Mian Li, Min Xu, Yu Xu, Yufang Bi, Weiqing Wang, Yuhong Chen, Jieli Lu

期刊论文

dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospectivecohort study

期刊论文

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospectivecohort study

期刊论文

for allogeneic peripheral stem cell transplantation for adult patients with lymphoid malignancies: a prospectivesingle-arm phase II study

Ling Wang, Lining Wang, Xing Fan, Wei Tang, Jiong Hu

期刊论文

aspiration to key hole craniotomy in the surgical treatment of spontaneous putaminal hemorrhage: a prospectiverandomized study

ZHAO Jizong, WANG Dejiang, WANG Shuo, YUAN Ge, KANG Shuai, JI Nan, ZHAO Yuanli, YE Xun, ZHOU Liangfu, ZHOU Dingbiao, WANG Renzhi, WANG Mei

期刊论文

during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma: a prospectivecohort study

Maura Massimino, Marta Podda, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Carlo Morosi, Filippo Spreafico, Andrea Ferrari, Emilia Pecori, Monica Terenziani

期刊论文

Prospective research on the efficacy and safety of oxcarbazepine as monotherapy and add-on therapy for

Huicong KANG, Xiaoyan LIU, Hu QI, Feng XU, Xiang LI, Yuan WANG, Zhiguang LIU, Suiqiang ZHU

期刊论文

厦金大桥地区地震危险性远景探讨

彭阜南,叶银灿,潘国富,刘杜娟

期刊论文

Scale study of sites and pavilions for World Expo 2010

ZHOU Zhuoyan, CHEN Yi

期刊论文

Practicality study on air-powered vehicle

LIU Lin, YU Xiaoli

期刊论文

Experimental study on shear behavior of prestressed reactive powder concrete I-girders

Hui ZHENG, Zhi FANG, Bin CHEN

期刊论文

A feasibility study of the measuring accuracy and capability of wireless sensor networks in tunnel monitoring

Xiaojun LI, Zhong JI, Hehua ZHU, Chen GU

期刊论文

Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical

null

期刊论文

Genetic study and molecular breeding for high phosphorus use efficiency in maize

null

期刊论文

Parametric study on seismic performance of self-centering reinforced concrete column with bottom-placed

期刊论文